Compared with control, Vox led to a slight decrease (not significant) of Cxcl1 expression in cancer cells, to a strong downregulation of Cxcl5 in total immune cells and macrophages, and to a modest upregulation of Cxcl2 in tumor macrophages (online supplemental figure 3A). This evidence concerns the gene CXCL1 and neoplasm.