MMP9 and squamous cell carcinoma: Menthol activation of TRPM8 similarly enhanced motility of squamous cell carcinoma lines by increasing matrix metallopeptidase-9 activity69 and knockdown or antagonism of TRPM8 inhibited migration of osteosarcoma cancer cell lines.70 The migration of epiblast cells is an evolutionarily conserved process, and its dysregulation could cause under or overdevelopment of organs.