Besides, IL-17 was also found to take part in initiation and development of experimental PAH via mice model, human pulmonary arterial endothelial cells or human pulmonary arterial smooth muscle cells.33, 34, 35 Targeting IL-17 would attenuate hypoxia-induced PAH through downregulation of β-catenin.35 Here, IL17A is linked to pulmonary arterial hypertension.