For example, interleukin signaling was enriched in genes from RBNSig of LIHC and LUAD only, and the enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and catalytic subunit of polycomb repressive complex 2 (PRC2) was specific to RBNSig of LIHC, lung squamous cell carcinoma, and sarcoma. This evidence concerns the gene PRDM9 and squamous cell lung carcinoma.