ORC1 and Fanconi anemia: The STRING protein clusters revealed an enrichment for key hallmarks of Rb-associated dysregulation including (i) events in G1 phase and G1-S transition associated with cyclin D and E (CCNE1, CCNE2, CDKN2A, E2F1, and RB1), (ii) the prereplicative complex and DNA replication (CDC45, CDC7, CDCA7, CDT1, MCM2, and ORC1), (iii) the Fanconi anemia pathway (CLSPN, FANCA, FANCE, and RAD54L), and (iv) chromosome condensation (CDC20, CDCA3, CENPA, DEPDC1, FAM83D, and SKA1) (table S3; Materials and Methods: Enrichment analysis).