As expected, genes down-regulated in RBNSig-BC included key markers of cell cycle control, such as RB1 and CCND1, but also genes from a diverse range of molecular processes including AP-1 transcription factor complex (FOS and FOSB), neuronal system (SLC18A2 and SYT1), hemostasis (SERPINA5, F10, F13A1, and MMRN1), and immunoregulatory signaling (FCER1A, MS4A2, and CD22) (table S3). This evidence concerns the gene MS4A2 and breast cancer.