The SYK, XIAP, ABCB1, FLT3, MAPK8, and CDK6 genes selected after comprehensive consideration were subjected to relevant clinical analysis in the GEPIA database, and SYK, XIAP, and CDK6 were statistically significantly upregulated in the analysis of GC and paraneoplastic correlation, as shown in Fig 5I. Here, MAPK8 is linked to gastric cancer.