Along with their antihypertensive effectiveness, a special consideration for their potential effects on the heart and oxidative stress was explored by measuring a number of gene expression profiles, e.g., angiotensin-1 (AT1), angiotensin-2 (AT2), ACE1, and ACE2, as well as inflammatory/anti-inflammatory mediators, e.g., nuclear factor kappa B (NF-κB), interleukin-6 (IL-6), nuclear factor erythroid 2-related factor 2 (Nrf2), and other biomarkers incovolved in the pathophysiology of hypertension, dyslipidemia, impaired glucose metabolism, and oxidative stress. This evidence concerns the gene ACE and Hypertension.