Presumably, this would result in mistargeting and impaired NHE3 function in patients, a pattern that is also seen in MVID patients (Vogel et al. 2017; Vogel, Klee, Vogel et al. 2015a, b; Vogel, van Rijn, Vogel et al. 2017a, b). Here, SLC9A3 is linked to microvillus inclusion disease.