Ezrin has been identified as an apical marker in intestinal epithelial cells that was lost from the apical membrane and accumulated either in the cytoplasm or on the basal side of enterocytes in MVID patients, contributing to the conclusion of MVID representing a cell polarity defect (Ameen and Salas 2000; Michaux et al. 2016). Here, EZR is linked to microvillus inclusion disease.