Regarding the cellular uptake of amyloids in the progression of neurodegenerative diseases, HS proteoglycans on the surface of neuronal cells play a critical role in the binding of extracellular aggregates of the Aβ protein, prion protein, or tau protein, and the uptake of aggregates into neuronal cells to seed the further aggregation of normal intracellular proteins [74,75]. The gene discussed is MAPT; the disease is neurodegenerative disease.