0.535–2.507 mg/kg ZEN decreased TOR phosphorylation in the hindgut.1.041–2.507 mg/kg ZEN increased enteritis morbidity upon Aeromonas hydrophila challenge, affected immune parameters in the intestines, decreased protein expression of T-TOR and TOR phosphorylation in different gut segments, and increased NF-κB p65 protein expression in foregut and hindgut. This evidence concerns the gene NFKB1 and enteritis.