The expression of 20 proteins (VEGFA, CD8A, uPA, SCF, ST1A1, AXIN1, TRAIL, CST5, ADA, CASP-8, FGF-5, 4E-BP1, MMP-1, MMP-10, TNFRSF9, Flt3L, HGF, ARTN, SIRT2, and STAMBP) were identified as being significantly altered after HK1651 infection compared to unstimulated Cas9 and/or caspase-1- and caspase-4-deficient cells (Figure 3). Here, CASP8 is linked to infection.