The protein expression of nine proteins (CD8A, ST1A1, AXIN1, ADA, CASP-8, 4E-BP1, HGF, SIRT2, STAMBP) was significantly decreased and the protein expression of four proteins (MMP-1, MMP-10, TNFRSF9, Flt3L) was significantly increased in caspase-4-deficient cells compared to Cas9 cells following HK1651 infection (Figure 3). The gene discussed is SIRT2; the disease is infection.