Associations of cystoisosporiasis in Ghanaian HIV patients with reduced CD4+ T-lymphocyte counts and increased HIV viral loads, immune-activation as indicated by reduced CD4+/CD8+ T-lymphocyte ratios as well as higher expression of HLA-DR+ CD38+ on CD4+ T-lymphocytes, a symptom complex comprising diarrhea, weight loss and a reduced BMI, a trend towards not being on antiretroviral medication, and lacking access to food safety procedures like storing food in refrigerators were shown. This evidence concerns the gene CD38 and isosporiasis.