In the context of patients with concomitant heart failure, observations from the study by Ignatavičiūtė et al. can be used, in which parameters such as treatment interruption, higher value of NT-proBNP, estimated glomerular filtration rate (eGFR) ≤ 50 mL/min/1.73 m2, systolic blood pressure (BP) ≤ 135 mmHg, and severe tricuspid valve regurgitation were additional predictors of LOHS [54]. This evidence concerns the gene NPPB and heart failure.