PAX8 and thyroid cancer, nonmedullary, 2: Indeed, PPARγ overexpression suppresses the PTEN-inhibitory action on AKT, resulting in activation of the PI3K signaling pathway, while PAX8-PPARγ rearrangement, a chromosomal translocation between the 5′ portion of PAX8 and the coding exons of PPARγ and detected in up to 60% of cases of follicular thyroid cancer (FTC), may directly induce the MAPK pathway [142,151].