In particular, the canonical NF-κB pathway, which controls several aspects of cell growth and survival, inflammation, and immune response, is implicated in the regulation of thyroid physiology, participating in the expression of various thyroid-specific genes, including NIS, PAX8, TG, TPO, and TTF-1, and also contributes to the development of several neoplasms, including TC, enhancing the proliferation and viability of thyroid neoplastic cells and their potential to migrate and colonize distant sites [128,129,130]. This evidence concerns the gene TG and thyroiditis.