After excluding death, malignancy-related AEs, and COVID-19, a total of 454 statistically significant AE signals were identified across the five ALK-TKIs: crizotinib (104 signals), ceritinib (89 signals), alectinib (94 signals), brigatinib (52 signals), and lorlatinib (115 signals). The gene discussed is ALK; the disease is COVID-19.