TARDBP and neurodegenerative disease: Figure 1 shows the neuropathological hallmarks of AD, PD, and TDP-43 pathology in children and young adults in Metropolitan Mexico City (MMC) versus elderly people in a community-based cohort at the University of Kentucky: the neurodegenerative diseases are the same [18]. UFPM and NPs resulting from combustion processes (including ubiquitous anthropogenic combustion emissions, wildfires, and domestic use of wood/pellets/stoves/ fireplaces), friction-derived nanoparticles, and industrial sources are at the core of the problem [5,7].