DNA adducts can induce mutations, triggering the development of adenomas in the small intestine, at an HMF consumption of 500 mg/kg of weight in mice [69], in addition to generating other negative changes in processes related to DNA transcription and replication, inducing one or more mutations, mainly for the activation of oncogenes such as H-ras and K-ras and changes in the tumor suppressor gene p53 [70]. This evidence concerns the gene TP53 and adenoma.