In addition, a study by Dachs et al. [105] showed that microglia do not promote MN destruction, as in the mouse model with a more severe SMA phenotype (FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd/J) microgliosis was not present in the ventral horn of the lumbar spinal cord at the end of the animals life span of 6 days, when MN loss was maximal. The gene discussed is SMN2; the disease is proximal spinal muscular atrophy.