WEE1 and ovarian carcinoma: However, myrocin D (89) and myrocin A (90) showed no inhibitory activity for the protein kinase and weak activities against K-562, A2780 (human ovarian cancer line), and A2780CisR (cisplatin-resistant human ovarian cancer cells), with IC50 values of 50.3, 41.3, 66.0, and 42.0, 28.2, 154.7 μM, respectively, with cisplatin used as the positive control (IC50 = 7.80, 0.80, and 8.40 μM) [37].