AKT1 and rheumatoid arthritis: In addition, we also found that the four absorbed components in plasma, namely, scopoletin, methyl caffeate, protocatechuic acid, and ferulic acid, had strong binding capacities with ALB and AKT1, respectively, through molecular docking validation, suggesting that scopoletin, caffeic acid methyl ester, protocatechuic acid, and ferulic acid of IPE may exert anti-RA effects by regulating ALB and AKT1.