The KEGG enrichment analysis (Figure 3C) revealed that these genes were significantly enriched in various signaling pathways and metabolic pathways, including Kaposi sarcoma-associated herpesvirus infection, valine, leucine, and isoleucine biosynthesis, neurotrophin signaling pathway, natural killer cell mediated cytotoxicity, chemokine signaling pathway, other carbon fixation pathways, T cell receptor signaling pathway, Ras signaling pathway, and colorectal cancer. The gene discussed is BDNF; the disease is colorectal cancer.