Metabolomic profiling further demonstrated beneficial shifts in renal metabolites, particularly a reduction in TMAO, a known biomarker of kidney damage linked to inflammation, fibrosis, oxidative stress, and thrombosis via activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome and nuclear factor-κB (NF-κB) signaling. The gene discussed is NLRP3; the disease is Nephropathy.