ALDH2 and pachyonychia congenita: Figure 6B demonstrates the Cox regression analysis results, including overall survival (OS) and recurrence-free survival (RFS), which revealed that ALDH2 was a protective factor in PC prognosis in nine datasets (HR < 1, p < 0.05). The Kaplan–Meier curve was then plotted, and the results of multiple datasets further revealed that ALDH2 was closely associated with a better prognosis for PC (Figure 6C–P). In addition, we also found that ALDH2 was closely associated with a lower tissue grade in PC (Figure 6Q).