PKM2 inhibitors 3K and SIRT inhibitor MHY2245 effectively inhibit the expressions of PKM2 and disrupt glycolysis via modulating the Akt/AMPK/mTOR signaling pathway, which induces G2/M cell cycle arrest and autophagy, and inhibits colony formation ability and proliferation of cancer cells [176,177]. The gene discussed is PKM; the disease is cancer.