Lijun Hu et al. used the cationic polymer APEG-PAsp (PEI) (PAPEI) for siRNA delivery to silence LDHA, inhibiting the M2-like polarization of tumor-associated macrophages and weakening immune suppression, effectively enhancing the anticancer effects of oxaliplatin (OXA) in colorectal cancer [362]. Here, LDHA is linked to neoplasm.