CRP and endothelial dysfunction: Furthermore, a well-established connection exists between inflammation and endothelial dysfunction, underscoring the importance of anti-inflammatory interventions in preserving endothelial health [138], and several studies have demonstrated beneficial effects of the OO on inflammatory markers including IL-6, C-reactive protein (CRP), TNF-α, vascular cell adhesion protein-1 (VCAM-1), and soluble intercellular adhesion molecule-1 (sICAM-1) [139,140].