In a myocardial ischemia/reperfusion model, the reduction in serum IL-1β was associated with the decrease in protein levels of phospho-IκBα (p-IκBα, an inhibitor of NF-κB), as well as the kinases phospho-MEK (p-MEK) and phospho-ERK (p-ERK). The gene discussed is NFKBIA; the disease is myocardial ischemia.