NFKB1 and myocardial ischemia: Additionally, HT was shown to mediate the downregulation of IL-6 transcription [73,74], additionally, OLE interferes with LPS-induced Toll-like receptor 4 (TLR4) dimerization, thereby alleviating inflammation by disrupting the TLR4-MyD88-NF-κB/MAPK signaling axis [75] in an in vivo model of myocardial ischemia/reperfusion, and in experimental autoimmune myocarditis [64,65,66,67,68,69,70,71,72,73,74,75,76].