AGXT and ischemic cardiomyopathy: In mice, SPT and Cerswere found to be increased following AMI (2 and 10 weeks); in this experimental model, a blockade of SPT with myriocin decreased Ceraccumulation in ischemic cardiomyopathy and reduced C16, C24:1, and C24Cers, as well as improving post AMI ventricular remodeling, fibrosis, and macrophage content.