Initial PHQ-2 (median 2 [1, 4] points) and GAD-2 (median 3 [2, 4] points) scores were high, indicating significant depression and anxiety symptoms, and these scores didn’t change at the end of Phase 2 CRP (median 3 [2, 5] and 4 [3, 5] points, respectively). The gene discussed is CRP; the disease is depressive disorder.