Ghrelin’s potential as a treatment for PAD in diabetic patients was suggested by a study on diabetic mice and ghrelin knockout mice showing that exogenous ghrelin contributes to vascular repair following hindlimb ischemia by improving blood flow recovery, enhancing angiogenesis, and reducing fibrosis through specific microRNAs, such as miRNA-126 and miRNA-132 [69]. This evidence concerns the gene GHRL and peripheral arterial disease.