CD80 and atherosclerosis: The increased number of infiltrating CD68-, CD80-positive macrophages, and CD14-positive monocytes in the GHSR-1a (+) patients that are usually associated with chronic inflammation in atherosclerosis indicated increased macrophage infiltration and M1 macrophage polarization, leading to the release of pro-inflammatory cytokines, such as IL-6 [57], which was found in abundance in our samples.