CD274 and neoplasm: Similarly, a study by Wang et al. demonstrated a pH-responsive nanoplatform combining doxorubicin and photosensitizers, which induced increased ATP secretion and dendritic cell maturation in vitro [24].Importantly, recent studies have shown that integrating ICD-inducing nanotherapies with immune checkpoint blockade (e.g., PD-1/PD-L1 inhibitors) significantly enhances tumor regression, with some platforms achieving complete tumor suppression in 80–100% of treated mice [25,26].