Recent research has shown that elevated levels of STIM1 and IP3R contribute to cyst growth by increasing the cAMP levels and promoting Ca+2 release from the ER, as demonstrated using STIM1 knockdown and pkd1 knockout in an ADPKD mouse model compared to non-cystic controls [69]. This evidence concerns the gene STIM1 and autosomal dominant polycystic kidney disease.