The results showed that the depletion of endogenous PC1 in HEK293 cells increased serum-induced Ca+2 oscillations and cell proliferation, while PC1-mutated kidney cystic cell lines exhibited similar abnormalities, which were reduced by exogenous PC1 expression, highlighting PC1 role in regulating Ca+2 homeostasis and cell cycle progression in ADPKD [55]. The gene discussed is PKD1; the disease is Renal cyst.