UBE2C and colorectal carcinoma: In contrast, protein overexpression in CRC organoids was observed for ubiquitin-conjugating enzyme E2C (UBE2C), which is reported to play an essential role in cell progression [145], and for HspBP1, a co-chaperone that inhibits the activity of Hsp70 and was also found to be overexpressed in several tumors [146].