Moreover, while we provide an extensive characterization of selected cytotoxicity-related markers on γδ T cells in CLL, we acknowledge that the analysis does not encompass other key activating receptors, such as DNAM-1 or NKG2D, or inhibitory molecules like PD-1, which have been implicated in cell exhaustion and immune surveillance. The gene discussed is KLRK1; the disease is B-cell chronic lymphocytic leukemia.