Furthermore, the activation of multiple inflammation-related signatures, including the inflammatory response, IFN responses, and IL6/JAK/STAT3 signaling, was observed in tumors with high CIN scores, especially in subpopulations with unknown causes of resistance to EGFR-TKIs, compared to tumors with low CIN scores (Figure 2A). This evidence concerns the gene EGFR and cervical squamous intraepithelial neoplasia.