Analysis of the genetic alterations in EFR3A in human neoplasms (cBioportal cancer genomics datasets) revealed that pancreatic ductal adenocarcinoma (PDAC) exhibits the highest EFR3A amplification frequency (almost 12% of cases) compared to, e.g., nonsmall cell lung cancer (NSCLC) and colorectal cancer (~5%). The gene discussed is EFR3A; the disease is cancer.