One study explored the contribution of PI(4)Kα to sialylation in MDA-MB-231 breast cancer cells, showing that the depletion of PI(4)Kα impairs the synthesis and localization of PI(4)P in the TGN, decreases N-glycan sialylation on the cell surface, and affects Akt phosphorylation, and integrin α3-mediated cell migration [63]. The gene discussed is PI4KA; the disease is breast cancer.