While the monotherapies with both Losartan or EV only partially detained the renal myofibroblast infiltration (2.8 ± 0.3 and 3.0 ± 1.1, respectively), the association of LOS + EV reversed the accumulation of interstitial α-SMA to values lower than those observed in basal CKD group and statistically similar to those observed in sham animals (1.5 ± 0.4 vs. 0.6 ± 0.1% in sham rats, ns). This evidence concerns the gene ACTA1 and chronic kidney disease.