ACTA1 and chronic kidney disease: Illustrative microphotographs of immunohistochemistry for α-SMA can be seen in Figure 7A. Once more, CKD rats presented significant interstitial accumulation of myofibroblasts at 15 days after renal ablation (3.7 ± 0.6 vs. 0.6 ± 0.1% in sham rats, p < 0.05), which raised only numerically after 30 days of CKD induction in the untreated group (4.2 ± 0.6%).