The lack of effect of an irreversible LSD1 inhibitor on basal fibrotic gene expression but for COL1A2 in SSc fibroblasts, together with the more profound changes caused by knockdown of LSD1, suggests a non-canonical, demethylase-independent role for LSD1 in maintenance of pro-fibrotic gene expression in SSc dermal fibroblasts. Here, KDM1A is linked to systemic sclerosis.