Interestingly, inhibition or silencing of LSD1 in oesophageal squamous cell carcinoma cell lines led to the downregulation of NOTCH1, NOTCH3, and HES1, and in small-cell lung cancer, it led to the downregulation of the Notch ligand DLL4 [34,35], suggesting that LSD1 could modulate Notch signalling by mechanisms independent of HOTAIR. This evidence concerns the gene DLL4 and small cell lung carcinoma.