This analysis identified pathways such as the longevity-regulating pathway (Hspa8 Irs2 Irs1 Hspa1a), IL-17 signaling pathway (Fosb Fos Lcn2 Cxcl10), FoxO signaling pathway (Gadd45b Gadd45g Plk2 Irs2 Irs1), insulin resistance (Tbc1d4 Irs2 Irs1 Ppp1r3c), MAPK signaling pathway (Gadd45b Hspa8 Fos Gadd45g Myc Nr4a1 Hspa1a), etc. The enrichment FDR and fold enrichment scores are provided in Table 7. The gene discussed is PLK2; the disease is Insulin resistance.