Particularly, malfunctioning microglia have been described as secreting chronically high levels of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 [20], thereby potentially contributing to the development of both psychiatric and neurodegenerative disorders including depression, Alzheimer’s, Parkinson’s, and ALS [21]. This evidence concerns the gene TNF and amyotrophic lateral sclerosis.