PKM2 expression showed a 3.7-fold increase in the GDM-I placentas (median and IQR values of 1.38 and 0.48; p < 0.01) and a 2.0-fold increase in the GDM-D placentas (median and IQR values of 0.38 and 0.2; p < 0.04) as compared with controls (Figure 4A,B). The gene discussed is PKM; the disease is gestational diabetes.