PKM and gestational diabetes: When comparing PKM2 protein expression in the treatment samples, there was a 1.5-fold increase difference (p < 0.002) between the GDM-I placental tissues and the GDM-D ones (median and IQR values for GDM-I and GDMD groups were 11.1, 0.91 and 3.1, 0.33 and 0.48, respectively; Figure 4C).