Phospho (p) PKM2, associated with the inactive form, was decreased 1.5-fold in GDM-I placentas (median and IQR values of 0.97 and 0.5; p < 0.03) and 2.7-fold (median and IQR values of 0.6 and 0.2; p < 0.05) in the GDM-D placentas as compared with controls (Figure 4D,E). This evidence concerns the gene PKM and gestational diabetes.