Importantly, CD276 expressed by glioma cells/GSCs may influence the differentiation of tumor-associated macrophages, i.e., increase the production of IL-10 and Mannose Receptor C-Type 1 (MRC1/CD206) while inhibiting Major Histocompatibility Complex, Class II, DR Alpha (HLA-DRA) expression on macrophages [69]. This evidence concerns the gene IL10 and central nervous system cancer.