Comparison of data obtained from serum samples revealed 86 candidate exosomal biomarkers in both serum and saliva, while eleven of them repeated in both sources, supporting their role as lung cancer biomarkers (Ig lambda-7 chain C region; Vimentin; Phospholipid transfer protein, isoform CRA_c; Lactoperoxidase; Proteasome subunit alpha type; Annexin; Zinc-alpha-2-glycoprotein; Grancalcin; Cysteine-rich secretory protein 3; Protein S100; Myeloblastin; Trefoil factor 3; Calpain small subunit 1; and Histone H3) [49]. Here, CRISP3 is linked to lung cancer.