CAFs associated with BCC exhibit increased expression of cathepsin K (CTSK), matrix Gla protein (MGP), cartilage intermediate layer protein (CLIP), dermatopontin (DPT), secreted frizzled-related protein 2 (SRFP2) and platelet-derived growth factor receptor-like protein ligand (PDGFRL) [792]. The gene discussed is CTSK; the disease is skin basal cell carcinoma.