S100A4 and cancer: During cancer development, adipocytes gradually lose their characteristic features (secretion of adiponectin, leptin, resistin, FABP4) and transform into cells expressing markers typical for fibroblasts (α-SMA-α smooth muscle actin, S100A4; ferroptosis suppressor protein 1, FSP-1; plasminogen activator inhibitor-1, PAI-1; and MMP9 and 11).