NK cell cytotoxicity can be modulated by immunosuppressive cytokines released by Tregs and MDSCs within the tumor mass, as well as by pro-inflammatory cytokines (IL-12, IL-15, IL-18, IL-21) and glioblastoma-derived TGF-β [72,199,200,201,202]. The gene discussed is TGFB1; the disease is glioblastoma.