POU5F1 and cancer: In MDA-MB-231 cells, GATAD2B knockdown significantly reduced expression of cancer stem-like cells factors OCT4, SOX2, c-Myc and NANOG, at both protein (Figure 2C) and mRNA level (Figure 2D), further implicating the role of GATAD2B in maintaining cancer stem-like cells phenotype in breast cancer cells.