In our study, the Wnt/β-catenin pathway not only directly promotes lung fibrosis induced by SARS-CoV-2 but also has crosstalk with multiple signaling pathways, including the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/AKT) signaling pathway and Janus kinases (JAK)/ signal transducer and activator of transcription (STAT) signaling pathway. The gene discussed is AKT1; the disease is pulmonary fibrosis.