NDUFS8 and neurodegenerative disease: IF regulates lipid metabolism primarily via genes including FABP4, WNT10B, PCK1, PLIN1, LEPR, and ADIPOQ, providing energy for cold adaptation, whereas PF positively influences in vivo degenerative diseases mainly through genes such as ATP5F1A, ATP5PO, SDHB, NDUFS8, SDHA, and COX5A.