It was observed that when LINC00261 expression was increased in CRC cells through expression vector-based methods, the expression of pro-apoptotic proteins such as BAX (BCL2-associated X protein), FAS (FS-7-associated surface antigen, Fas receptor), Bim (Bcl-2-interacting mediator of cell death), and cleaved caspase-3 increases, which in turn reduced cell viability and migration of CRC cells by increasing E-cadherin and reducing EMT proteins such as MMP2 and MMP9 (Matrix Metalloproteinase-9) [35]. The gene discussed is CASP3; the disease is colorectal carcinoma.