LINC00261 expression is significantly downregulated in pancreatic cancer (PC) cell lines, including AsPC-1 (Ascites Pancreatic Cancer-1), BxPC-3 (Biopsy xenograft of Pancreatic Carcinoma line-3), PANC-1 (Pancreatic Cancer-1), and CFAC-1 (cystic fibrosis pancreatic adenocarcinoma cell line), compared to normal pancreatic ductal epithelial cells (HPDE6-C7). The gene discussed is LINC00261; the disease is pachyonychia congenita.