Specifically, LINC00261 suppresses the PI3K/Akt/mTOR (Phosphatidylinositol-3-kinase (PI3K), Protein kinase B (AKT), and Mammalian target of rapamycin (mTOR) signaling pathway by interacting with KLF13 (Krüppel-like factor 13) in pancreatic cancer, thereby reducing metastasis and invasive characteristics. Here, KLF13 is linked to familial pancreatic carcinoma.