Antidiabetic agents, such as Metformin, Dipeptidyl Peptidase-4 (DPP-4) inhibitors, Sulfonylurea, Glinides, Sodium–Glucose Co-Transporter 2 inhibitors (SGLT2is), glucagon-like peptide-1 (GLP-1) Receptor Agonists, α-glycosidase inhibitors, and thiazolidinediones (TZDs), are effective, safe, and widely used in the treatment of diabetes. The gene discussed is DPP4; the disease is diabetes mellitus.