MTOR and autism: Stafstrom et al. explained the decreased seizure threshold and neuronal hyperexcitability that occur in autism, in the case of Fragile X Syndrome, by a disorder of regulation of glutamate-mediated neuronal transmission, and, in the case of Tuberous Sclerosis Complex, by the interruption of the mTOR pathway that leads to the production of cortical tubers, which are epileptogenic neuropathological lesions associated with cognitive deficit and autism [19].