The following characteristics are assessed before the start of the radiotherapy course: medical history, medication, age, body mass index, Karnofsky performance score, bladder volume, prostate volume, tumor stage, histology, Gleason score, level of prostate-specific antigen (PSA), risk group of prostate cancer, dose fractionation parameters, treatment volume, technique of radiotherapy, and patient’s smart phone experience and need for support. Here, KLK3 is linked to prostate cancer.